The Mouse Anti-Retinal Pigment Epithelium Specific Protein 65kDa Antibody from MyBioSource.com is a Mouse Monoclonal antibody to retinoid isomerohydrolase RPE65, and RPE65. This antibody recognizes Bovine antigen. The Mouse Anti-Retinal Pigment Epithelium Specific Protein 65kDa Antibody has been validated for the following applications: Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
Highly conserved among vertebrate species, RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE